Chemical modifications including the use of dinucleotide mRNA cap analogues with locked nucleic acid (LNA) substitutions enhance translation and stability 0.3. It is important to ensure effective translation of the mRNA therapeutic into the desired protein in vivo. To enhance mRNA stability and to create a new research modality for COVID–19, adenine (A), cytosine (C), guanine (G), thymidine (T) could be replaced by their phosphorothioate derivatives which will protect the RNA strands from degradation thereby increasing its half-life in the organism.